Anti-Human CD366/Tim-3 (F38-2E2) - 169Tm - 100 Tests

T cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) is a type I transmembrane receptor that is constitutively expressed at high levels on NK cells, and also expressed on specific subsets of CD4+ and CD8+ T cells, on subpopulations of macrophages and DCs, and on monocytes, although to a lesser extent than on NK cells. Tim-3 was originally identified as a marker of terminally differentiated CD4+ Th1 cells, and subsequently associated with T cell exhaustion and impaired virus-specific T cell responses in HIV-1, hepatitis C virus (HCV), and hepatitis B virus (HBV) infection. To date, three ligands have been described for Tim-3, including galectin-9 (Gal-9), cell-surface phosphatidylserine, and the high-mobility group box 1 (HMGB1) protein. Gal-9 is highly expressed in immune tissues, and engagement of Tim-3 by Gal-9 triggers apoptosis in CD4+ Th1 cells, T cells, and thymocytes. Tim-3 signaling on immune cells can trigger either inhibitory or activating signals.

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    100 Tests

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