Anti-Human CD274/PD-L1 (MIH1) - 209Bi - 25 Tests

PD-L1 (also known as CD274, B7-H1), one of the ligands for programmed death 1 (PD-1), is an immune-inhibitory receptor belonging to the CD28/cytotoxic T lymphocyte antigen 4 (CTLA-4) family. It can deliver an inhibitory signal to PD-1/B7-1-expressing T cells, resulting in immune-suppressive effects. PD-L1 is expressed on activated T cells, B cells, NK cells, DCs, macrophages, and bone marrow-derived mast cells. PD-L1 expression is also found on a wide range of human tumors such as kidney, ovarian, bladder, breast, liver, gastric, pancreatic and non-small cell lung cancer (NSCLC). Most important, these studies reveal that higher expression of PD-L1 may facilitate advancement of tumor stage and increase the invasion potential. PD-L1 expression can be induced by many inflammatory mediators and cytokines, of which interferon-γ (IFN-γ) is the most potent. Blockade of the PD-1/PD-L1 interaction has been shown to reverse immune exhaustion and is a critical target of current immunotherapeutics.

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    25 Tests

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