327 results found in C1

• technical note

  Processing Flow-Sorted Cryopreserved Cells for C1 mRNA Sequencing Applications Technical Note 

• User Guide

  Genomics Instruments Safety Guide 

  Safety Information for Genomics Instruments

• system

  C1

  The first automated solution for single-cell genomics, now capable of even more …

• Publications

  Nuclear RNA-seq of single neurons reveals molecular signatures of activation

  Single-cell sequencing methods have emerged as powerful tools for identification of heterogeneous cell types within defined brain regions. …

• Publications

  Combating subclonal evolution of resistant cancer phenotypes

  Metastatic breast cancer remains challenging to treat, and most patients ultimately progress on therapy. …

• Publications

  Characteristics of allelic gene expression in human brain cells from single-cell RNA-seq data analysis

  Monoallelic expression of autosomal genes has been implicated in human psychiatric disorders. …

• Publications

  Identification of genes expressed in a mesenchymal subset regulating prostate organogenesis using tissue and single cell transcriptomics

  Prostate organogenesis involves epithelial growth controlled by inductive signalling from specialised mesenchymal subsets. …

• Publications

  High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin

  Understanding cell type identity in a multicellular organism requires the integration of gene expression profiles from individual cells with their spatial location in a particular tissue. …

• Publications

  NGS-Logistics: federated analysis of NGS sequence variants across multiple locations

  As many personal genomes are being sequenced, collaborative analysis of those genomes has become essential. …

• Publications

  Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate

  The erythroid stress cytokine erythropoietin (Epo) supports the development of committed erythroid progenitors, but its ability to act on upstream, multipotent cells remains to be established. …

• Publications

  Laser microdissection of the alveolar duct enables single-cell genomic analysis

  Complex tissues such as the lung are composed of structural hierarchies such as alveoli, alveolar ducts, and lobules. …

• Publications

  Biased allelic expression in human primary fibroblast single cells

  The study of gene expression in mammalian single cells via genomic technologies now provides the possibility to investigate the patterns of allelic gene expression. …

• Publications

  Human germ cell formation in xenotransplants of induced pluripotent stem cells carrying X chromosome aneuploidies

  Turner syndrome is caused by complete or partial loss of the second sex chromosome and is characterized by spontaneous fetal loss in >90% of conceptions. …

• Publications

  Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus

  Germline GATA1 mutations that result in the production of an amino-truncated protein termed GATA1s (where s indicates short) cause congenital hypoplastic anemia. …

• Publications

  Single-cell genetic analysis using automated microfluidics to resolve somatic mosaicism

  Somatic mosaicism occurs throughout normal development and contributes to numerous disease etiologies, including tumorigenesis and neurological disorders. …

• Publications

  Sox7 is regulated by ETV2 during cardiovascular development

  Vasculogenesis/angiogenesis is one of the earliest processes that occurs during embryogenesis. …

• Publications

  MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data

  Single-cell transcriptomics reveals gene expression heterogeneity but suffers from stochastic dropout and characteristic bimodal expression distributions in which expression is either strongly non-zero or non-detectable. …

• Publications

  Classification of low quality cells from single-cell RNA-seq data

  Single-cell RNA sequencing (scRNA-seq) has broad applications across biomedical research. …

• Publications

  CEL-Seq2: sensitive highly-multiplexed single-cell RNA-seq

  Single-cell transcriptomics requires a method that is sensitive, accurate, and reproducible. …

• Publications

  SINCERA: a pipeline for single-cell RNA-seq profiling analysis

  A major challenge in developmental biology is to understand the genetic and cellular processes/programs driving organ formation and differentiation of the diverse cell types that comprise the embryo. …