Phenotyping

Unique spatial landscapes and comprehensive phenotypic analysis bring insight

Understanding the presence and location of stromal, tumor and immune cells and how they interact in the tissue or tumor microenvironment is key to obtaining new insights into disease pathophysiology and therapeutic response. The features listed below demonstrate how rich Imaging Mass Cytometry™ (IMC™) data has been used to harness the power of high-plex imaging to explore tissue structure, function and phenotype at the single-cell level.

Blue icon illustrating phenotyping application

Revealing heterogeneity of inflammatory bowel disease (IBD)

 

 

A team led by Klaus Kaestner, PhD, in the Department of Genetics at the University of Pennsylvania Perelman School of Medicine developed a panel that can be used to quantify the heterogeneous nature of IBD and how immune cells interact within the spatial environment of this disease. Learn how expansive characterization using IMC helps close gaps in knowledge about diseases.

Uncovering COVID-19 lung pathology

Headshot Olivier Elemento BW

 

Weill Cornell Medicine scientists recently accomplished an important step forward in understanding lung pathology and immune response to COVID-19 in the Nature publication “The spatial landscape of lung pathology during COVID-19 progression.” Learn how a team led by Olivier Elemento, PhD, Director of the Englander Institute for Precision Medicine and Cornell University Professor of Physiology and Biophysics, was able to view not only the structure of the tissue but also the interplay between infected cells and the immune system in COVID-19 patients.

Non-random signaling clusters in glioblastoma

Headshot Rebecca Ihrie BW

 

Rebecca Ihrie, PhD, Associate Professor of Cell and Developmental Biology at Vanderbilt University, discusses her glioblastoma research to identify and associate cell-to-cell variation and distribution within different tumors to phenotypes, extending stratification work done using mass cytometry. Ihrie highlights how she has performed high-multiplex analysis in dual-mode capacity, generating data from both tissue samples and cells in suspension using CyTOF® mass cytometry.

Characterization of hepatic adaptive and innate immune sets in hepatitis B virus

Headshot Kyong Mi Chang BW

 

 

Research led by Kyong-Mi Chang, MD, Professor of Medicine (GI) at the University of Pennsylvania Perelman School of Medicine, shows marked correlations between adaptive and innate immune microenvironment with relevance to hepatitis B viral pathogenesis. Learn how the comprehensive phenotypic analysis was performed and correlated with hepatocellular injury, inflammation and fibrosis.

Publications

Powering over 1,500 scientific publications with our products

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Febe van Maldegem, PhD, and Karishma Valand

Spotlight IMC FEBE VAN MALDEGEM, PHD, AND KARISHMA VALAND

Imaging the dramatic remodeling of the lung tumor microenvironment

Melissa Davis, PhD

Spotlight IMC MELISSA DAVIS

Defining spatial characteristics using Imaging Mass Cytometry

Bernd Bodenmiller, PhD

Spotlight IMC Bodenmiller

Bernd Bodenmiller on revealing new insights into tumors with Imaging Mass Cytometry

CUSTOMER STORIES

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Unless explicitly and expressly stated otherwise, all Fluidigm products are provided for Research Use Only, not for use in diagnostic procedures. For more information see www.fluidigm.com/legal/notices