Browse our catalog of Hyperion™ Imaging System-related publications to see how Imaging Mass Cytometry™ systems from Fluidigm empower researchers to make breakthrough discoveries.
Get the most up-to-date IMC Bibliography:Download
-
Overview
Number of papers per research area as of January, 2021Number of cumulative papers as of January, 2021 -
Recent
-
A single-cell atlas of the tumor and immune ecosystem of human breast cancer
Wagner, J., Rapsomaniki, M.A., Chevrier, S. et al. Cell (2019): 1,330-45 -
Human lymphoid organ cDC2 and macrophages play complementary roles in T follicular helper responses
Durand, M., Walter, T., Pirnay, T. et al. Journal of Experimental Medicine (2019): 1,561-1,581 -
TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry
Bassan, J., Willis, L.M. Vellanki, R.N. et al. Proceedings of the National Academy of Sciences (2019): doi: 10.1073/pnas.1821151116 -
Lymphocyte mass cytometry identifies a CD3–CD4+ cell subset with a potential role in psoriasis
Guo, R., Zhang, T., Meng, X. et al. JCI Insight (2019): 125,306 -
Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry
Carvajal-Hausdorf, D.E., Patsenker, J., Stanton, K.P. et al. Clinical Cancer Research (2019): 3,054–62
-
A single-cell atlas of the tumor and immune ecosystem of human breast cancer
-
Research Areas
-
Data Analysis Methods
-
Methods for analyzing tellurium Imaging Mass Cytometry data
Bassan, J. and Nitz, M. PLoS One (2019): e0221714 -
ImaCytE: Visual exploration of cellular microenvironments for Imaging Mass Cytometry data
Somarakis, A., van Unen, V., Koning, F. et al. IEEE Transactions on Visualization and Computer Graphics (2019): doi: 10.1109/TVCG.2019.2931299. -
histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data
Schapiro, D., Jackson, H.W., Raghuraman, S. et al. Nature Methods (2017): 873–6 -
Compensation of signal spillover in suspension and Imaging Mass Cytometry
Chevrier, S., Crowell, H.L., Zanotelli, V.R.T. et al. Cell Systems (2018): 612–20 -
Automatic single cell segmentation on highly multiplexed tissue images
Schüffler, P.J., Schapiro, D., Giesen, C. et al. Cytometry, Part A; (2015): 936–42
-
Methods for analyzing tellurium Imaging Mass Cytometry data
-
Immuno-oncology
-
Molecular MRI of the immuno-metabolic interplay in a rabbit liver tumor model: A biomarker for resistance mechanisms in tumor-targeted therapy?
Savic, L.J., Doemel, L. A., Schobert, I.T. Radiology (2021): DOI: 10.1148/radiol.2020200373 -
Expression analysis and significance of PD-1, LAG-3, and TIM-3 in human non-small cell lung cancer using spatially resolved and multiparametric single-cell analysis
Datar, I., Sanmamed, M.F., Wang, J. et al. Clinical Cancer Research (2019): 4663–73 -
The potential application of PD1 blockade therapy for early stage biliary tract cancer
Umemoto, K., Togashi, Y., Arai, Y., et al. International Immunology (2019): doi: 10.1093/intimm/dxz080 -
Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma
Chew, V., Lee, Y.H., Nasir, N.J.M. et al. Gut (2018): 335–46 -
Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma
Raj, D., Yang, M.H., Rodgers, D. et al. Gut (2018): 1052–64 -
Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry
Carvajal-Hausdorf, D.E., Patsenker, J., Stanton, K.P. et al. Clinical Cancer Research (2019): 3,054–62
-
Molecular MRI of the immuno-metabolic interplay in a rabbit liver tumor model: A biomarker for resistance mechanisms in tumor-targeted therapy?
-
Immunology
-
Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue
Zhao, Y., Uduman, M., Siu, J.H.Y. et al. Nature Communications (2018): 3,857 -
Development of a 2-dimensional atlas of the human kidney with Imaging Mass Cytometry
Singh, N., Avigan, Z.M., Kliegel, J.A. et al. JCI Insight (2019): e129477 -
Highly multiplexed Imaging Mass Cytometry allows visualization of tumor and immune cell interactions of the tumor microenvironment in FFPE tissue sections
Singh, M., Chaudhry, P., Gerdtsson, E. et al. Blood (2017): 2,751 -
Opposing Roles of Dendritic Cell Subsets in Experimental GN
Brähler, S., Zinselmeyer, B.H., Raju, S. et al. Journal of the American Society of Nephrology (2018): 138–54 -
Memory CD4+ T cells are generated in the human fetal intestine
Li, N., van Unen, V., Abdelaal, T. et al. Nature Immunology (2019): 301–12
-
Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue
-
Immunophenotyping
-
High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease
Mrdjen, D., Pavlovic, A., Hartmann, F.J. et al. Immunity (2018): 380–95 -
Lymphocyte mass cytometry identifies a CD3–CD4+ cell subset with a potential role in psoriasis
Guo, R., Zhang, T., Meng, X. et al. JCI Insight (2019): 125,306
-
High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease
-
Infectious Disease/Microbiology
-
Inflammatory response cells during acute respiratory distress syndrome in patients with coronavirus disease 2019 (COVID-19)
Zhang, Y., Gao, Y., Qiao, L. Annals of Internal Medicine (2020): doi: 10.7326/L20-0227 -
Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice
Uraki, R., Hastings, A.K., Marin-Lopez, A. et al. Nature Microbiology (2019): 948-955
-
Inflammatory response cells during acute respiratory distress syndrome in patients with coronavirus disease 2019 (COVID-19)
-
Liquid Biopsy
-
Multiplex protein detection on circulating tumor cells from liquid biopsies using Imaging Mass Cytometry
Gerdtsson, E., Pore, M., Thiele, J.A. et al. Convergent Science Physical Oncology (2018): 015002
-
Multiplex protein detection on circulating tumor cells from liquid biopsies using Imaging Mass Cytometry
-
Method Development
-
A systematic comparison of in vitro cell uptake and in vivo biodistribution for three classes of gold nanoparticles with saturated PEG coatings
Zhang, Y., Liu, A. T., Cornejo, Y. R. PLOS One (2020): doi.org/10.1371/journal.pone.0234916 -
Rare osteosarcoma cell subpopulation protein array and profiling using Imaging Mass Cytometry and bioinformatics analysis
Batth, I.S., Meng, Q., Torres, K. E. BMC Cancer (2020): doi: 10.1186/s12885-020-07203-7 -
Metal-labeled aptamers as novel nanoprobes for Imaging Mass Cytometry analysis
Yu, Y., Dang, J., Liu, X. Analytical Chemistry (2020): doi: 10.1021/acs.analchem.9b05159 -
A 34-Marker Panel for Imaging Mass Cytometric Analysis of Human Snap-Frozen Tissue
Guo, N., Unen, V.V, Ijsselsteijn, M.E. Frontiers in Immunology (2020): doi.org/10.3389/fimmu.2020.01466 -
Signal amplification for Imaging Mass Cytometry
Rana, R., Gómez-Biagi, R.F., Bassan, J., et al. Bioconjugate Chemistry (2019): 2,805-2,810 -
Clickable and High-Sensitivity Metal-Containing Tags for Mass Cytometry
Allo, B., Lou, X., Bouzekri, A.. et al. Bioconjugate Chemistry (2018): 2,028–38 -
Highly stable and inert complexation of Indium(III) by reinforced cyclam dipicolinate and a bifunctional derivative for bead encoding in mass cytometry
Grenier, L., Beyler, M., Platas-Iglesias, C. et al. Chemistry (2019): doi: 10.1002/chem.201903969 -
DNA-conjugated gold nanoparticles as high-mass probes in Imaging Mass Cytometry
Malile, B., Brkic, J., Bouzekri, A. et al. ACS Applied Bio Materials (2019): doi: 10.1021/acsabm.9b00574 -
Multidimensional profiling of drug‐treated cells by Imaging Mass Cytometry
Bouzekri, A., Esch, A., and Ornatsky, O. FEBS Open Bio (2019): doi:10.1002/2211-5463.12692 -
Analytical figures of merit for a novel tissue imaging system
Straus, R.N., Carew, A., Sandkujil, D. et al. Journal of Analytical Atomic Spectrometry (2017): 1,044–51 -
Imaging Mass Cytometry
Chang, Q., Ornatsky, O.I., Siddiqui, I. et al. Cytometry Part A (2017): 160–9 -
Ruthenium Counterstaining for Imaging Mass Cytometry
Catena, R., Montuenga, L.M., Bodenmiller, B. Journal of Pathology (2018): 479–84 -
TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry
Bassan, J., Willis, L.M. Vellanki, R.N. et al. Proceedings of the National Academy of Sciences (2019): doi: 10.1073/pnas.1821151116 -
Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution
Edgar, L.J., Vellanki, R.N., McKee, T.D. et al Angewandte Chemie International Edition (2016): 13,159–63 -
Mass Spectrometry Imaging and Integration with Other Imaging Modalities for Greater Molecular Understanding of Biological Tissues
Porta Siegel, T., Hamm, G., Bunch, J. et al. Molecular Imaging and Technology (2018): 888-901 -
Simultaneous Detection of Protein and mRNA in Jurkat and KG-1a Cells by Mass Cytometry
Mavropoulos, A., Allo, B., He, M. et al. Cytometry Part A (2017): 1,200–8 -
Staining of frozen and formalin-fixed, paraffin-embedded tissues with metal-labeled antibodies for Imaging Mass Cytometry analysis
Chang, Q., Ornatsky, O., Hedley, D. Current Protocols in Cytometry (2017): 12.47.1–12.47.8 -
Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry
Giesen, C., Wang, H.A., Schapiro, D. et al. Nature Methods (2014): 417–22
-
A systematic comparison of in vitro cell uptake and in vivo biodistribution for three classes of gold nanoparticles with saturated PEG coatings
-
Neurology
-
The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions
Park, C., Ponath, G., Levine-Ritterman, M. et al. Acta Neuropathologica Communications (2019): 130
-
The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions
-
Oncology
-
Uncovering differently expressed markers and heterogeneity on human pancreatic cancer
Yoon, S., Li, H., Quintanar, L. Translational Oncology (2020): doi: 10.1016/j.tranon.2020.100749 -
The characterization of an aggregated three-dimensional cell culture model by multimodal mass spectrometry imaging
Flint, L.E., Hamm, G., Ready, J.D. Analytical Chemistry (2020): doi.org/10.1021/acs.analchem.0c02389 -
Single-cell transcriptome analysis reveals disease-defining T-cell subsets in the tumor microenvironment of classic Hodgkin lymphoma
Aoki, T.,Chong, L. C.,Takata, K. Cancer Discovery (2020): DOI: 10.1158/2159-8290.CD-19-0680 -
Systemic dysfunction and plasticity of the immune macro environment in cancer models
Allen, B. M.,Hiam, K. J., Burnett C. E. Nature Medicine (2020): DOI: 10.1038/s41591-020-0892-6 -
Imaging mass cytometry and multiplatform genomics define the phenogenomic landscape of breast cancer
Ali, H.R., Jackson, H.W., Zanotelli, Z.R.T. et al. Nature Cancer (2020): 163-175. -
The single-cell pathology landscape of breast cancer
Jackson, H.W., Fischer, J.R., Zanotelli, V.R. et al. Nature (2020): 615-620. -
Cancer-associated fibroblasts promote immunosuppression by inducing ROS-generating monocytic MDSCs in lung squamous cell carcinoma
Xiang, H., Ramil, C.P., Hai, J. et al. Cancer Immunology Research (2020): 436-450 -
Skin platinum deposition in colorectal cancer patients following oxaliplatin-based therapy
Cao, Y., Chang, Q., Zhang, W. et al. Cancer Chemotherapy and Pharmacology (2019): 1-6 -
Immunocyte profiling using single-cell mass cytometry reveals EpCAM+ CD4+ T cells abnormal in colon cancer
Zhang, T., Lv, J., Tan, Z. et al. Frontiers in Immunology (2019): doi: 10.3389/fimmu.2019.01571 -
Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts
Elyada, E., Bolisetty, M., Laise, P. et al. Cancer Discovery (2019): doi: 10.1158/2159-8290.CD-19-0094. -
Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues
Chang, Q., Ornatsky, O.I., Siddiqui, I. et al. Scientific Reports (2016): 36,641 -
Simultaneous Multiplexed Imaging of mRNA and Proteins with Subcellular Resolution in Breast Cancer Tissue Samples by Mass Cytometry
Schulz, D., Zanotelli, V.R.T., Fischer, J.R. et al. Cell Systems (2018): 25–36 -
Clonal diversity revealed by morphoproteomic and copy number profiles of single prostate cancer cells at diagnosis
Malihi, P.D., Morikado, M., Welter, L. et al. Convergent Science Physical Oncology (2018): doi: 10.1088/2057-1739/aaa00b
-
Uncovering differently expressed markers and heterogeneity on human pancreatic cancer
-
Review
-
The use and limitations of single‐cell mass cytometry for studying human microglia function
Fernández‐Zapata, C., Leman, J. K. H., Priller, J. Brain Pathology (2020): doi.org/10.1111/bpa.12909 -
Deciphering immunity at high plexity and resolution
Domínguez Conde, C. and Teichmann, S. Nature Reviews Immunology (2019): 77-78 -
The islets of Langerhans continue to reveal their secrets
Bonner-Wei, S. Nature Reviews Endocrinology (2019): 73-74 -
Mass cytometry imaging for the study of human diseases – applications and data analysis strategies
Baharlou, H., Canete, N.P., Cunningham, A.L. et al. Frontiers in Immunology (2019): doi: 10.3389/fimmu.2019.02657 -
The reconstructed natural history of type 1 diabetes mellitus
Pozzilli, P. and Signore, A. Nature Reviews Endocrinology (2019): 256-257 -
Considerations for immunohistochemistry
Balaji, S., Li, H., Steen, E. et al. Success in Academic Surgery: Basic Science (2019): 105-144 -
The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes
Nakayasu, E.S., Qian, W.J., Evans-Molina, C. et al. Expert Review of Proteomics (2019): 569-582
-
The use and limitations of single‐cell mass cytometry for studying human microglia function
-
Stem Cell
-
Human lymphoid organ cDC2 and macrophages play complementary roles in T follicular helper responses
Durand, M., Walter, T., Pirnay, T. et al. Journal of Experimental Medicine (2019): 1,561-1,581
-
Human lymphoid organ cDC2 and macrophages play complementary roles in T follicular helper responses
-
Other
-
Smooth muscle cell reprogramming in aortic aneurysms
Chen, P.-Y., Qin, L., Li, G. et al. Cell Stem Cell (2020): 542-557. -
Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry
Ramaglia, V., Sheikh-Mohamed, S., Legg, K. et al. eLife (2019): e48051 -
A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry
Damond, N., Engler, S., Zanotelli, V.R.T. et al. Cell Metabolism (2019): doi: 10.1016/j.cmet.2018.11.014 -
Imaging Mass Cytometry and single-cell genomics reveals differential depletion and repletion of B-cell populations following ofatumumab treatment in cynomolgus monkeys
Theil,D., Smith,P., Huck, C. et al. Frontiers in Immunology (2019): 1,340 -
Multiplexed in situ Imaging Mass Cytometry analysis of the human endocrine pancreas and immune system in type 1 diabetes
Wang, Y.J., Traum, D., Schug, J. et al. Cell Metabolism (2019): doi: 10.1016/j.cmet.2019.01.003
-
Smooth muscle cell reprogramming in aortic aneurysms
-