Hyperion Imaging System Publications

Browse our catalog of Hyperion™ Imaging System-related publications to see how Imaging Mass Cytometry™ systems from Fluidigm empower researchers to make breakthrough discoveries.

• Overview

  Number of papers per research area as of August, 2019

  Number of cumulative papers as of August, 2019

• Recent

  • A single-cell atlas of the tumor and immune ecosystem of human breast cancer
    Wagner, J., Rapsomaniki, M.A., Chevrier, S. et al. Cell (2019): 1,330-45
  • Human lymphoid organ cDC2 and macrophages play complementary roles in T follicular helper responses
    Durand, M., Walter, T., Pirnay, T. et al. Journal of Experimental Medicine (2019): 1,561-1,581
  • TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry
    Bassan, J., Willis, L.M. Vellanki, R.N. et al. Proceedings of the National Academy of Sciences (2019): doi: 10.1073/pnas.1821151116
  • Lymphocyte mass cytometry identifies a CD3–CD4+ cell subset with a potential role in psoriasis
    Guo, R., Zhang, T., Meng, X. et al. JCI Insight (2019): 125,306
  • Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry
    Carvajal-Hausdorf, D.E., Patsenker, J., Stanton, K.P. et al. Clinical Cancer Research (2019): 3,054-62

• Research Areas

  • Data Analysis Methods

    • histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data
      Schapiro, D., Jackson, H.W., Raghuraman, S. et al. Nature Methods (2017): 873–6
    • Compensation of signal spillover in suspension and Imaging Mass Cytometry
      Chevrier, S., Crowell, H.L., Zanotelli, V.R.T. et al. Cell Systems (2018): 612–20
    • Automatic single cell segmentation on highly multiplexed tissue images
      Schüffler, P.J., Schapiro, D., Giesen, C. et al. Cytometry, Part A; (2015): 936–42

  • IO

    • Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry
      Carvajal-Hausdorf, D.E., Patsenker, J., Stanton, K.P. et al. Clinical Cancer Research (2019): 3,054-62
    • Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma
      Chew, V., Lee, Y.H., Nasir, N.J.M. et al. Gut (2018): doi: 10.1136/gutjnl-2017-315485
    • Expression analysis and significance of PD-1, LAG-3, and TIM-3 in human non-small cell lung cancer using spatially resolved and multiparametric single-cell analysis
      Datar, I., Sanmamed, M.F., Wang, J. et al. Clinical Cancer Research (2019): doi: 10.1158/1078-0432.CCR-18-4142.
    • Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma
      Raj, D., Yang, M.H., Rodgers, D. et al. Gut (2018): doi: 10.1136/gutjnl-2018-316595

  • Immunology

    • Development of a 2-dimensional atlas of the human kidney with Imaging Mass Cytometry
      Singh, N., Avigan, Z.M., Kliegel, J.A. et al. JCI Insight (2019): doi: 10.1172/jci.insight.129477
    • Highly Multiplexed Imaging Mass Cytometry Allows Visualization of Tumor and Immune Cell Interactions of the Tumor Microenvironment in FFPE Tissue Sections
      Singh, M., Chaudhry, P., Gerdtsson, E.. et al. Blood (2017):
    • Opposing Roles of Dendritic Cell Subsets in Experimental GN
      Brähler, S., Zinselmeyer, B.H., Raju, S. et al. Journal of the American Society of Nephrology (2018): 138–54
    • Memory CD4+ T cells are generated in the human fetal intestine
      Li, N., van Unen, V., Abdelaal, T. et al. Nature Immunology (2019): 301–12
    • Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue
      Zhao, Y., Uduman, M., Siu, J.H.Y. et al. Nature Communications (2018): 3,857

  • Immunophenotyping

    • High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease
      Mrdjen, D., Pavlovic, A., Hartmann, F.J. et al. Immunity (2018): 380–95
    • Lymphocyte mass cytometry identifies a CD3–CD4+ cell subset with a potential role in psoriasis
      Guo, R., Zhang, T., Meng, X. et al. JCI Insight (2019): 125,306

  • Infectious Disease/Microbiology

    • Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice
      Uraki, R., Hastings, A.K., Marin-Lopez, A. et al. Nature Microbiology (2019): 948-955

  • Inherited Disease

    • A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry
      Damond, N., Engler, S., Zanotelli, V.R.T. et al. Cell Metabolism (2019): doi: 10.1016/j.cmet.2018.11.014

  • Liquid Biopsy

    • Multiplex protein detection on circulating tumor cells from liquid biopsies using Imaging Mass Cytometry
      Gerdtsson, E., Pore, M., Thiele, J.A. et al. Convergent Science Physical Oncology (2018): 015002

  • Method Development

    • Analytical figures of merit for a novel tissue imaging system
      Straus, R.N., Carew, A., Sandkujil, D. et al. Journal of Analytical Atomic Spectrometry (2017): 1,044–51
    • Imaging Mass Cytometry
      Chang, Q., Ornatsky, O.I., Siddiqui, I. et al. Cytometry Part A (2017): 160–9
    • Ruthenium Counterstaining for Imaging Mass Cytometry
      Catena, R., Montuenga, L.M., Bodenmiller, B. Journal of Pathology (2018): 479–84
    • Clickable and High-Sensitivity Metal-Containing Tags for Mass Cytometry
      Allo, B., Lou, X., Bouzekri, A.. et al. Bioconjugate Chemistry (2018): 2,028-38
    • TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry
      Bassan, J., Willis, L.M. Vellanki, R.N. et al. Proceedings of the National Academy of Sciences (2019): doi: 10.1073/pnas.1821151116
    • Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution
      Edgar, L.J., Vellanki, R.N., McKee, T.D. et al Angewandte Chemie International Edition (2016): 13,159–63
    • Mass Spectrometry Imaging and Integration with Other Imaging Modalities for Greater Molecular Understanding of Biological Tissues
      Porta Siegel, T., Hamm, G., Bunch, J. et al. Molecular Imaging and Technology (2018): 888-901
    • Simultaneous Detection of Protein and mRNA in Jurkat and KG-1a Cells by Mass Cytometry
      Mavropoulos, A., Allo, B., He, M. et al. Cytometry Part A (2017): 1,200–8
    • Staining of frozen and formalin-fixed, paraffin-embedded tissues with metal-labeled antibodies for Imaging Mass Cytometry analysis
      Chang, Q., Ornatsky, O., Hedley, D. Current Protocols in Cytometry (2017): 12.47.1–12.47.8
    • Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry
      Giesen, C., Wang, H.A., Schapiro, D. et al. Nature Methods (2014): 417–22

  • Oncology

    • Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts
      Elyada, E., Bolisetty, M., Laise, P. et al. Cancer Discovery (2019): doi: 10.1158/2159-8290.CD-19-0094.
    • Immunocyte profiling using single-cell mass cytometry reveals EpCAM+ CD4+ T cells abnormal in colon cancer
      Zhang, T., Lv, J., Tan, Z. et al. Frontiers in Immunology (2019): doi: 10.3389/fimmu.2019.01571
    • Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues
      Chang, Q., Ornatsky, O.I., Siddiqui, I. et al. Scientific Reports (2016): 36,641
    • Simultaneous Multiplexed Imaging of mRNA and Proteins with Subcellular Resolution in Breast Cancer Tissue Samples by Mass Cytometry
      Schulz, D., Zanotelli, V.R.T., Fischer, J.R. et al. Cell Systems (2018): 25–36
    • Clonal diversity revealed by morphoproteomic and copy number profiles of single prostate cancer cells at diagnosis
      Malihi, P.D., Morikado, M., Welter, L. et al. Convergent Science Physical Oncology (2018): doi: 10.1088/2057-1739/aaa00b

  • Review

    • The reconstructed natural history of type 1 diabetes mellitus
      Pozzilli, P. and Signore, A. Nature Reviews Endocrinology (2019): 256-257
    • Considerations for immunohistochemistry
      Balaji, S., Li, H., Steen, E. et al. Success in Academic Surgery: Basic Science (2019): 105-144
    • The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes
      Nakayasu, E.S., Qian, W.J., Evans-Molina, C. et al. Expert Review of Proteomics (2019): 569-582

  • Stem Cell

    • Human lymphoid organ cDC2 and macrophages play complementary roles in T follicular helper responses
      Durand, M., Walter, T., Pirnay, T. et al. Journal of Experimental Medicine (2019): 1,561-1,581

  • Other

    • Imaging Mass Cytometry and single-cell genomics reveals differential depletion and repletion of B-cell populations following ofatumumab treatment in cynomolgus monkeys
      Theil,D., Smith,P., Huck, C. et al. Frontiers in Immunology (2019): 1,340
    • Multiplexed in situ Imaging Mass Cytometry analysis of the human endocrine pancreas and immune system in type 1 diabetes
      Wang, Y.J., Traum, D., Schug, J. et al. Cell Metabolism (2019): doi: 10.1016/j.cmet.2019.01.003